Even the most thoughtful and steadfast investor is susceptible to the influence of skeptics who yell 'Sell' before it's time to sell…We've all been taught the same adages: 'Take profits when you can,' and 'A sure gain is always better than a possible loss.' But when you've found the right stock and bought it, all the evidence tells you it's going higher, and everything is working in your direction, then it's a shame if you sell. A fivefold gain turns $10,000 into $50,000, but the next five folds turn $10,000 into $250,000. Investing in a 25-bagger is not a regular occurrence even among fund managers, and for the individual, it may only happen once or twice in a lifetime. When you've got one, you might as well enjoy the full benefit.